Reaction of blood pressure and mesenteric blood flow to infusion of biogenic amines in normal and supralethally x-irradiated rats

Journal Article · Tue Apr 01 04:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575239· OSTI ID:5022895

Timmermans, R; Gerber, G B

The responss of blood pressure and mesenteric blood flow were recorded during infusion of biogenic amines (noradrenaline, dopamine, serotonin, acetylcholine, and histamine) to control and x-irradiated rats (first and third days after 2 kR x irradiation). Responses to different doses of the amines were evaluated, and the results obtained correspond to those seen in other species (e.g., an increase in pressure and a decrease in flow after dopamine, an increase in pressure and a decrease in flow after serotonin, a decrease in pressure and flow after acetylcholine, and a decrease in flow after serotonin, a decrease in pressure and flow after acetylcholine, and a decrease in pressure and an increase in flow after histamine). Irradiated animals are more responsive to pressure-raising agents, in particular to noradrenaline. They also have an altered dose-pressure response curve for dopamine.

• Research Organization: EURATOM, Mol, Belgium
• OSTI ID: 5022895
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 82:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLCHOLINE
ADRENAL HORMONES
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AROMATICS
AZOLES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BLOOD PRESSURE
COMPARATIVE EVALUATIONS
DATA
DOPAMINE
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HISTAMINE
HORMONES
HYDROXY COMPOUNDS
IMIDAZOLES
INDOLES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
KINETICS
MAMMALS
MEMBRANES
MESENTERY
NORADRENALINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASYMPATHOMIMETICS
PHENOLS
POLYPHENOLS
PYRROLES
QUATERNARY COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RODENTS
SEROTONIN
SEROUS MEMBRANES
STEROID HORMONES
SUPRALETHAL IRRADIATION
SYMPATHOMIMETICS
TRYPTAMINES
VERTEBRATES
X RADIATION