INVESTIGATIONS ON THE PROBLEM OF FORMATION AND PATHOPHYSIOLOGICAL SIGNIFICANCE OF BIOGENIC AMINES IN SUBLETHAL RADIATION INJURIES. Quarterly Technical Status Report No. 3, May 1-July 31, 1962
Fluorescencc spectrophotometric determinations of 7 biogenic amines (dopamine, 1-noradrenaline, adrenaline, tryptamine, 5-hydroxytryptamine, bufotenine, and histsmine) were carried out in the urine of rats treated with whole-body irradiation. The rats received subcutaneously from the first day post irradiation phenylacetic acid (6 single doses) or alpha-methyl-dopa (3 single doses) dissolved in sterofundin. Phenylacetic acid reduced the radioinduced overexcretion of noradrenaline and adrenaline only moderately but reduced tryptamine, 5-hydroxytryptamine, and bufotenine nearly completely, and that of dopamine and histamine totally. Alpha-methyl-dopa reduced the radioinduced overexcretion of tryptamine, 5hydroxytryntamine, bufotenine, and histamine about 50% from the first day after irradiation. (P.C.H.)
- Research Organization:
- Cologne. Universitat. Medizinische Klinik
- NSA Number:
- NSA-16-028834
- OSTI ID:
- 4795305
- Report Number(s):
- NP-11982
- Country of Publication:
- United States
- Language:
- English
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