INVESTIGATIONS ON THE PROBLEM OF FORMATION AND PATHOPHYSIOLOGICAL SIGNIFICANCE OF BIOGENIC AMINES IN SUBLETHAL RADIATION INJURIES. Quarterly Technical Status Report No. 3, May 1-July 31, 1962

Technical Report · Tue Jul 31 04:00:00 EDT 1962

OSTI ID:4795305

Franzen, Fr

Fluorescencc spectrophotometric determinations of 7 biogenic amines (dopamine, 1-noradrenaline, adrenaline, tryptamine, 5-hydroxytryptamine, bufotenine, and histsmine) were carried out in the urine of rats treated with whole-body irradiation. The rats received subcutaneously from the first day post irradiation phenylacetic acid (6 single doses) or alpha-methyl-dopa (3 single doses) dissolved in sterofundin. Phenylacetic acid reduced the radioinduced overexcretion of noradrenaline and adrenaline only moderately but reduced tryptamine, 5-hydroxytryptamine, and bufotenine nearly completely, and that of dopamine and histamine totally. Alpha-methyl-dopa reduced the radioinduced overexcretion of tryptamine, 5hydroxytryntamine, bufotenine, and histamine about 50% from the first day after irradiation. (P.C.H.)

• Research Organization: Cologne. Universitat. Medizinische Klinik
• NSA Number: NSA-16-028834
• OSTI ID: 4795305
• Report Number(s): NP-11982
• Country of Publication: United States
• Language: English

Related Subjects

ADRENALINE
AMINES
BIOLOGY AND MEDICINE
BODY
BUFOTENINE
CHEMICALS
DOPAMINE
DRUGS
FLUORESCENCE
HISTAMINE
HORMONES
IRRADIATION
PHENYLALANINE
PHOTOMETRY
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION SICKNESS
RATS
SEROTONIN
SPECTROMETERS
TRYPTAMINES
URINE