The effects of early postoperative radiation on vascularized bone grafts

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Annals of Plastic Surgery; (United States)

DOI:https://doi.org/10.1097/00000637-199106000-00002· OSTI ID:5011382

Evans, H B; Brown, S; Hurst, L N ^[1]

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1. Division of Plastic and Reconstructive Surgery, University of Western Ontario, London (Canada)

The effects of early postoperative radiation were assessed in free nonvascularized and free vascularized rib grafts in the canine model. The mandibles of one-half of the dogs were exposed to a cobalt 60 radiation dose of 4080 cGy over a 4-week period, starting 2 weeks postoperatively. The patency of vascularized grafts was confirmed with bone scintigraphy. Histological studies, including ultraviolet microscopy with trifluorochrome labeling, and histomorphometric analyses were performed. Osteocytes persist within the cortex of the vascularized nonradiated grafts to a much greater extent than in nonvascularized, nonradiated grafts. Cortical osteocytes do not persist in either vascularized or nonvascularized grafts subjected to radiation. New bone formation is significantly retarded in radiated grafts compared with nonradiated grafts. Periosteum and endosteum remained viable in the radiated vascularized grafts, producing both bone union and increased bone turnover, neither of which were evident to any significant extent in nonvascularized grafts. Bone union was achieved in vascularized and non-vascularized nonradiated bone. In the radiated group of dogs, union was only seen in the vascularized bone grafts.

• OSTI ID: 5011382
• Journal Information: Annals of Plastic Surgery; (United States), Journal Name: Annals of Plastic Surgery; (United States) Vol. 26:6; ISSN APCSD; ISSN 0148-7043
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE CELLS
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DOGS
DOSES
GRAFTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
SKELETON
SOMATIC CELLS
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOT