Blood pressure and urinary sodium and potassium excretion in cadmium-treated male rats

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80110-4· OSTI ID:5001996

Nishiyama, S; Nakamura, K; Konishi, Y

Subcutaneous injection of cadmium chloride (as CdCl/sub 2/) in the backs of male Wistar rats at the four doses of 0.01, 0.1, 0.5, and 1.0 mg/kg body wt was performed twice a day for 7 consecutive days and the animals were maintained without any treatment for an additional period up to 60 days. Treatment with 0.1, 0.5, and 1.0 mg Cd markedly decreased the urinary Na and K excretion from Day 1 to Day 3. The significant increase in blood pressure of rats treated with 0.1 mg Cd was not present from Day 8 to Day 32 during which the water retention significantly increased. The blood pressure of rats treated with 1.0 mg Cd significantly increased although the increase in water and Na retention was not observed on Day 32. These observations suggest that the decrease in the urinary excretion of Na and the increase in water retention may be not associated with the main factor for the elevation of the blood pressure induced by Cd. Cd concentrations in the heart, abdominal aorta, and lung of rats treated with 1.0 mg Cd were markedly lower than those in the liver and kidney. Changes in the level of Ca and Mg were only observed in the lungs and not in the heart and aorta.

• Research Organization: Kochi Medical School, Japan
• OSTI ID: 5001996
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 40:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METALS
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BODY
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CALCIUM
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
EDEMA
ELEMENTS
EXCRETION
EXPERIMENTAL DATA
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEART
INFORMATION
INJECTION
INTAKE
KIDNEYS
LIVER
LUNGS
MAGNESIUM
MAMMALS
METALS
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
POTASSIUM
RATS
RESPIRATORY SYSTEM
RETENTION
RODENTS
SODIUM
SUBCUTANEOUS INJECTION
SYMPTOMS
TISSUE DISTRIBUTION
VERTEBRATES