Urinary excretion of cyclic AMP in cadmium-intoxicated rats

Journal Article · Sun Jan 01 04:00:00 EST 1989 · Journal of Toxicology and Environmental Health; (USA)

DOI:https://doi.org/10.1080/15287398909531302· OSTI ID:5030110

Ando, Masanori; Matsui, Sachiko; Jinno, Hideto; Takeda, Mitsuharu ^[1]

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1. National Institute of Hygienic Sciences, Tokyo (Japan)

To obtain further information on the negative calcium balance cased by Cd, the factors associated with serum calcium and phosphorus homeostasis other than inhibition of intestinal calcium absorption were studied by using cyclic 3{prime},4{prime}-adenosine monophosphate (cAMP). In rats exposed to Cd for 30 d, the levels of urinary excretion of cAMP after treatment with parathyroid hormone (PTH), parathyroidectomy (PTX), or 1{alpha}-hydroxycholecalciferol (1{alpha}-OH-D{sub 3}) showed almost the same patterns as those of control rats: the response of urinary cAMP to treatment with PTH was not influenced by continuous oral administration of Cd. On the other hand, in rats exposed to Cd for 90 d without the other three treatments, the amount of urinary excretion of cAMP was markedly higher than in control rats. In PTX rats exposed to 90 d of Cd, urinary cAMP was uncharged, but it was markedly increased when the parathyroid was intact, with or without treatment with PTX. This phenomenon indicated hyperparathyroidemia in response to continuous oral administration of continuous oral administration of Cd for 90 d. The negative calcium balance with hyperparathyroidemia occurred after continuous oral administration of Cd and developed via increased urinary excretion of calcium. Urinary excretion of cAMP in Cd-exposed rats was unaffected by the administration of 1{alpha}-OH-D{sub 3}.

• OSTI ID: 5030110
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Journal Name: Journal of Toxicology and Environmental Health; (USA) Vol. 27:3; ISSN JTEHD; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
AMP
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CADMIUM
CALCIUM
CLEARANCE
ELEMENTS
EXCRETION
HORMONES
KINETICS
MAMMALS
MATERIALS
METALS
NUCLEOTIDES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
PARATHORMONE
PEPTIDE HORMONES
RATS
REACTION KINETICS
RODENTS
TOXICITY
URINE
VERTEBRATES
WASTES