Metabolic balances of strontium in man

Journal Article · Tue Jun 01 04:00:00 EDT 1976 · Clin. Orthop.; (United States)

DOI:https://doi.org/10.1097/00003086-197606000-00041· OSTI ID:7286908

Warren, J M ^[1]; Spencer, H

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1. Royal Hospital for Sick Children, Glasgow

Stable strontium balances were determined in man under strictly controlled dietary conditions in control studies and during both oral and intravenous administration of stable strontium. The diet contained about 1 mg strontium per day and most of this (88%) was excreted in stool while 17.5% was excreted in urine, so that the balance was very slightly negative. During the oral intake of 1536 mg strontium per day, given as the lactate, the urinary and the fecal strontium excretions increased markedly and the balance became strongly positive. During the 6-day periods of intravenous infusions of stable strontium as the gluconate, 30-40% of the infused amount was excreted in the urine and 5-10% in stool. A high percentage of the strontium retained during both oral and intravenous administration was excreted in 30 days after the discontinuation of the strontium administration and there was no evidence of long term retention. The administration of stable strontium, given either orally or intravenously, was associated with an increase of the urinary calcium excretion.

• OSTI ID: 7286908
• Journal Information: Clin. Orthop.; (United States), Journal Name: Clin. Orthop.; (United States) Vol. 117; ISSN CORPA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CALCIUM
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ELEMENTS
EXCRETION
FECES
INJECTION
INTAKE
INTRAVENOUS INJECTION
MAMMALS
MAN
METABOLISM
METALS
ORAL ADMINISTRATION
PRIMATES
STRONTIUM
URINE
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