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Tissue disposition of zinc and copper following repeated administration of cadmium and selenium to rats

Journal Article · · Environ. Res.; (United States)
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Female rats were divided into four groups of five rats each including one control group (C). The animals were administered Na/sub 2/SeO/sub 3/ (Se), (CdCl/sub 2/Cd), and Na/sub 2/SeO/sub 3/ + CdCl/sub 2/ (Cd +Se). Sodium selenite was given intragastrically at a dose of 0.5 mg Se/kg every day and cadmium chloride was injected subcutaneously every other day at a dose of 0.3 mg Cd/kg for 2 weeks. Exposure of rats to Cd caused an increase in the concentration of copper in the kidneys, blood, and liver and a decrease in the lung, but increased the concentration of zinc in the liver and brain and diminished it in the muscles and bones. In animals exposed to Se an increase in the copper concentration was observed in blood and brain; zinc was increased in the blood, heart, brain, and stomach, but decreased in the kidneys. Exposure of rats to Cd + Se resulted in an increase of copper in the kidneys and a decrease in the spleen, lungs, stomach, muscles and bones. Se prevented the cadmium-induced diminution of the zinc levels in the muscles and bones.

Research Organization:
Institute of Environmental Research and Bioanalysis, Narutowicza, Poland
OSTI ID:
5091055
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 37:2; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CADMIUM
CENTRAL NERVOUS SYSTEM
COPPER
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
GLANDS
INFORMATION
KIDNEYS
LIVER
LUNGS
MAMMALS
MATERIALS
METABOLISM
METALS
MUSCLES
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
SELENIUM
SEMIMETALS
SKELETON
STOMACH
TISSUE DISTRIBUTION
TOXICITY
TRANSITION ELEMENTS
VERTEBRATES
ZINC