Disturbances in the metabolism of endogenous metals (Zn and Cu) in nickel-exposed rats

Journal Article · Sun Jan 31 23:00:00 EST 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90072-X· OSTI ID:5611321

Chmielnicka, J; Szymanska, J A; Tyfa, J

The effect of nickel chloride on tissue concentrations of zinc and copper was studied in female rats. Animals were subjected to repeated exposure to 5 mg Ni/kg. Whole-body retention of zinc increased about 30%, and retention of copper did not change. Increase of the zinc content was observed in liver, but in kidneys, lungs, and brain zinc content decreased. It was also noted that the level of metallothionein was higher in nickel-exposed rat liver than in control rat liver. Concentration of metallothionein was correlated with the metal contents (Ni, Cu, Zn).

• Research Organization: Medical Academy of Lodz, Poland
• OSTI ID: 5611321
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 27:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COPPER
DISTRIBUTION
ELEMENTS
FEMALES
HALIDES
HALOGEN COMPOUNDS
KIDNEYS
LUNGS
MAMMALS
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
NERVOUS SYSTEM
NICKEL
NICKEL CHLORIDES
NICKEL COMPOUNDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
ZINC