cDNA sequence, map, and expression of the murine homolog of GTBP, a DNA mismatch repair gene

Journal Article · Sun Sep 01 04:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0464· OSTI ID:486314

Corradi, A; Croci, L; Stayton, C L ^[1]

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1. San Raffaele Scientific Institute, Milan (Italy); and others

DNA mismatch repair genes (MMR) have been actively studied in humans for their roles in cancer susceptibility. Recently, GTBP, a new member of the MMR gene family, has been cloned and found to encode a 160-kDa protein that forms a heterodimer with hMSH2. Our group has isolated and characterized the mouse homolog of GTBP. The transcript, termed Gtmbp. The transcript, termed Gtmbp (G/T mismatch-binding protein), encodes a protein highly similar to its human counterpart. The gene is markedly conserved across species and maps to the distal portion of mouse chromosome 17, in a region homologous to human 2p. One Gtmbp-related sequence maps to proximal mouse chromosome 4. Studies of the expression of Gtmbp suggest that its regulated transcription is tightly linked to the level of DNA replication, consistent with the protein`s DNA proofreading function. 30 refs., 5 figs.

• OSTI ID: 486314
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 36; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AMINO ACID SEQUENCE
BIOLOGICAL EVOLUTION
CHROMOSOMES
DNA
DNA HYBRIDIZATION
DNA REPAIR
DNA REPLICATION
DNA SEQUENCING
DNA-CLONING
GENE REGULATION
GENES
GENETIC MAPPING
GENETIC RADIATION EFFECTS
HUMAN CHROMOSOME 2
IONIZING RADIATIONS
MICE
NEOPLASMS
POLYMERASE CHAIN REACTION
PROBES
PROTEINS
RISK ASSESSMENT
TRANSCRIPTION