Isolation and chromosomal mapping of a mouse homolog of the Batten disease gene CLN3

Journal Article · Thu Aug 01 04:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0410· OSTI ID:466004

Lee, R L ^[1]; Johnson, K R ^[2]; Lerner, T J ^[1]

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1. Massachusetts General Hospital, Charlestown, MA (United States)
2. Jackson Lab., Bar Harbor, ME (United States)

We describe the isolation and chromosomal mapping of a mouse homology of the Batten disease gene, CLN3. Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids. The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, and respectively. The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, where CLN3 maps. Isolation of a mouse CLN3 homolog will facilitate the creation of a mouse model of Batten disease. 8 refs., 2 figs.

• OSTI ID: 466004
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 35; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACIDS
BIOLOGICAL MODELS
CHROMOSOMES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
GENE MUTATIONS
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 16
MAN
MICE
NERVOUS SYSTEM DISEASES
NUCLEOTIDES
PROTEINS
RECESSIVE MUTATIONS
STRUCTURE-ACTIVITY RELATIONSHIPS