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EFFECTS OF X-RAY AND $beta$-RAY IRRADIATION ON THE OCCURRENCE OF EXPERIMENTAL CARCINOMA OF MICE

Journal Article · · Kanazawa Irigaku Sosho (Japan)
OSTI ID:4842118
When 0.3% 3: 4-benzpyrene was dripped onto adult mice, skin papilloma occurred in 20.7% and carcinoma in 67.9% of the animals. X irradiation with x- rays in total doses of 1600 to 2000 r caused the tumors to decrease slightly in size and the cancer cells, especially in the peripheral part, to degenerate. After irradiation with 25 and 50 mu c of Sr/sup 90/, degeneration of several cancer cells in the mitotic phase was observed in the superficial part of the tumor, but no change was noted in the deep part. The development of the carcinoma was strikingly inhibited and delayed by single prophylactic whole-body x irradiation before benzparene application. Development of the tumor was completely inhibited by prophylactic fractional whole-body irradiations. These results suggest that a substance was prcduced by x irradiation which suppressed the development of the carcinoma. (Abstr. Japan Med., 1: No. 1 0, 1961)
Research Organization:
Kanazawa Univ., Japan
NSA Number:
NSA-15-027439
OSTI ID:
4842118
Journal Information:
Kanazawa Irigaku Sosho (Japan), Journal Name: Kanazawa Irigaku Sosho (Japan) Vol. Vol: 53; ISSN KISOA
Country of Publication:
Country unknown/Code not available
Language:
English