INVESTIGATION OF THE ROLE OF IONIZING RADIATION IN EXPERIMENTAL INFECTION WITH PATHOGENIC STAPHYLOCOCCI

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Arch. roumaines pathol. exptl. microbiol.

OSTI ID:4839386

Nestoresco, N; Benes, S; Strimbeanu, I

Rabbits were irradiated with 50 r at 3- to 4-day intervals over a period of 44 days, giving a total radiation dose of 450 r. Three days after the last dose, a pathologic strain of Staphylococcus aureus was injected intravenously and the course of infection was followed in these and in infectednon-irradiated controls. The mortality by 90 days was twice as high in irradiated-infected than infected controls, whereas the irradiated-noninfected animals showed an intermediate mortality rate. The leukocytosis induced by infection was lower in irradiated animals, but agglutinin and antistaphylolysin titers were not appreciably lower in irradiated rabbits. Histopathologic changes were most marked in the irradiated-infected group and least severe in the nonirradiated- infected group, and these changes were most pronounced in intestine, spleen, and liver. Necrotizingdegenerative lesions in the central nervous system and adrenals could be attributed entirely to irradiation. (H.H.D.)

• Research Organization: Inst. Dr. I. Cantacuzino, Bucharest
• NSA Number: NSA-16-020257
• OSTI ID: 4839386
• Journal Information: Arch. roumaines pathol. exptl. microbiol., Journal Name: Arch. roumaines pathol. exptl. microbiol. Vol. Vol: 20
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADRENAL GLANDS
BACTERIA
BIOLOGY AND MEDICINE
BRAIN
IMMUNITY
INFECTIONS
INTESTINE
LEUCOCYTES
LIFETIME
LIVER
QUANTITY RATIO
RABBITS
RADIATION EFFECTS
RADIATION INJURIES
SPLEEN