CONTINUOUS COBALT-60 IRRADIATION AND IMMUNITY TO INFLUENZA VIRUS
Mice were exposed to Co/sup 60/ gamma rays at a dose rate of 9, 16, 33, or 106 r/day for total doses up to 2547 r. After 15 days exposure, they were infected with PR8 strain type A influenza virus and hemagglutination titers in their serum were followed. It was shown that continuous irradiation, both prior to and during the course of infection with influenza virus, results in a continued growth of virus particles in lungs of infected animals and results in much higher titers for longer periods of time than in nonirradiated animals. This ability for unsuppressed growth of virus in lungs of irradiated animals appears to be related to radiation dose. The phenomenon of prolongation of the interval for virus production was shown to be associated with an impaired ability to produce antibody in animals receiving the greatest gamma -radiation exposures. In the dosages utilized, irradiation interferes with primary influenza virus antibody response, but does not interfere with secondary antibody response. Differences observed between primary and secondary antibody responses could be related to effect of antigens on lymphocyte radiosensitivity. The possibility, however, that earlier stimulus had produced a larger number of antibodyproducing cells and that more cells require a greater amount of irradiation must also be considered. (H.H.D.)
- Research Organization:
- Loma Linda Univ., Los Angeles
- NSA Number:
- NSA-17-027123
- OSTI ID:
- 4661819
- Journal Information:
- Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 90; ISSN JOIMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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