Isotype profiles of anti-influenza antibodies in mice bearing the xid defect

Journal Article · Fri Feb 01 04:00:00 EST 1985 · J. Virol.; (United States)

OSTI ID:5445143

Reale, M A; Bona, C A; Schulman, J L

The humoral response to influenza A/PR8 virus was examined in the CAB/N and C/sub 3/J.xid strains of mice, both of which bear an X-linked genetic defect (xid), and in strains lacking this defect. Hemagglutination-inhibiting antibody titers and measurement of virus-specific antibodies by solid-phase radioimmunoassay indicated that the xid defect does not impair the production of an adequate anti-influenza antibody response. However, investigation of the isotopes of PR8 virus-specific antibodies disclosed a relative decrease in the levels of IgG3 and IgG1 in the xid-bearing strains. This was observed after both intraperitoneal immunization and aerosol infection. The isotope differences were not reflected in the susceptibility of these strains to influenza virus infection.

• Research Organization: City Univ. of New York, NY
• OSTI ID: 5445143
• Journal Information: J. Virol.; (United States), Journal Name: J. Virol.; (United States) Vol. 53:2; ISSN JOVIA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGGLUTININS
ANIMALS
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
HEMAGGLUTININS
INFLUENZA VIRUSES
ISOTOPE APPLICATIONS
MAMMALS
MICE
MICROORGANISMS
MUTANTS
PARASITES
RADIOASSAY
RADIOIMMUNOASSAY
RODENTS
TRACER TECHNIQUES
VERTEBRATES
VIRUSES