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Reduction of influenza virus pathogenesis by exposure to 0. 5 ppm ozone

Journal Article · · J. Toxicol. Environ. Health; (United States)
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Continuous exposure to 0.5 ppm ozone during the course of murine influenza A/PR8/34 virus infection reduced the severity of the disease as quantitated by histologic (morphometric), biochemical (serum albumin in lavage fluid), and gravimetric (lung wt/dry weight ratios) parameters of lung injury. The ozone-mediated abatement of the lung injury was independent of peak pulmonary virus titers. However, determination of the sites of virus multiplication indicated that exposure to ozone resulted in a less widespread infection of the lung parenchyma. Furthermore, ozone exposure reduced the antiviral immune response as shown by reduced numbers of phenotypically quantitated T- and B-lymphocytes recovered from lung tissues and reduction of serum antibody titers. Since the pathogenesis of influenza virus infection depends on both the site of viral replication and the antiviral immune response, these studies suggest that redistribution of virus growth in murine lungs and immunosuppressive mechanisms are factors in the ozone-reduced disease severity.

Research Organization:
Johns Hopkins School of Hygiene and Public Health, Baltimore, MD (USA)
OSTI ID:
7066317
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Journal Issue: 4 Vol. 23:4; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNE REACTIONS
INFECTIOUS DISEASES
INFLUENZA
INFLUENZA VIRUSES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MICROORGANISMS
ORGANIC COMPOUNDS
OZONE
PARASITES
PATHOGENESIS
PROTEINS
RODENTS
SOMATIC CELLS
VERTEBRATES
VIRAL DISEASES
VIRUSES