Mortality of X-Irradiated Mice Infected with Trichinella spiralis
Swiss mice were given 250, 350, 450, or 650 r and infected orally with 50, 100, or 200 larvae 24 hr after exposure to radiation. Radiation doses of 250 and 350 r followed by infection did not result in host mortality throughout the 28-day observation period. One death occurred 24 days after 450 r in the group of 32 mice infected with 100 worms, but all mice that received 200 worms after similar irradiation exposure survived. Fifteen of 24 mice given both 650 r radiation and infection died, whereas 1 of 8 animals died that had received oniy radiation. Thus infection with 50 to 200 worms given 24 hr after 650 r whole- body x radiation resulted in a greater likelihood of death than when the infection was omitted. It is suggested that the worms, by their migrations within the intestinal tissues, opened the way for bacterial invasion via the intestine, resulting in bacteremia. This would account for the higher mortality the 2nd week after moderately lethal irradiation doses.
- Research Organization:
- New York City Dept. of Health
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-010431
- OSTI ID:
- 4736647
- Journal Information:
- Journal of Parasitology, Journal Name: Journal of Parasitology Journal Issue: 1 Vol. 48; ISSN 0022-3395
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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