THE TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF HAFNIUM SALTS

Technical Report · Fri Sep 01 04:00:00 EDT 1961

OSTI ID:4832313

Haley, T J; Raymond, K; Komesu, N; Upham, H C

The toxicology and pharmacology of hafnium salts was investigated. Acute intraperitoneal toxicity of hafnyl chloride is of the delayed type with an LD/sub 50//7 days of 112(93.3 to 134.4) mg/kg. Chronic feeding for 90 days at levels of 1.0, 0.1, and 0.01% of the diet produced liver changes at the 1.0% level. No changes were observed in the growth rate or the hemogram. Ocular application to intact rabbit skin produced a transient mrrmtathon whereas similar studies on abraded skin resulted in nonhealing ulcers. Intradermal injections also produced localized irritation and scar formation. Hafnyl chloride had a depressant effect upon isolated rabbit and guinea pm-g ileum. In the intact cat, the compound produced hypotensioon and death by cardiovascular collapse and respiratory paralysis. The chemiocal had no effect on the responses to acetyhcholine, epinephrine, or histamine or those elmcited by stimulation of the cervical sympathetic or vagus nerves. (auth)

• Research Organization: California. Univ., Los Angeles. School of Medicine. Lab. of Nuclear Medicine and Radiation Biology
• NSA Number: NSA-16-002875
• OSTI ID: 4832313
• Report Number(s): UCLA-487
• Country of Publication: United States
• Language: English

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD VESSELS
CATS
CHLORIDES
DIET
EYES
GUINEA PIGS
HAFNIUM COMPOUNDS
INTESTINE
LETHAL DOSE
LIVER
LUNGS
NERVOUS SYSTEM
RABBITS
SALTS
SKIN
TOXICITY