THE PHARMACOLOGY AND TOXICOLOGY OF SCANDIUM CHLORIDE
Technical Report
·
OSTI ID:4798696
The pharmacological and toxicological properties of scandium chloride were investigated. The intraperitoneal and oral LD/sub 50's/ were 755 mg/kg and 4 gm/kg respectively. Studies of chronic toxicity showed no body weight changes occurred in any group except the male rats on a 1% dietary level. The hemograms of all animals were within the normal range, and histopathological examination of the tissues revealed no damage related to the ingestion of scandium chloride. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Pharmacological studies indicated that the chemical had a depressant action on all systems studied and produced lethality by respiratory paralysis coupled with cardiovascular collapse. The lethal effects could not be counteracted by atropinization or epinephrine administration. (auth)
- Research Organization:
- California. Univ., Los Angeles. School of Medicine. Lab. of Nuclear Medicine and Radiation Biology
- NSA Number:
- NSA-16-014426
- OSTI ID:
- 4798696
- Report Number(s):
- TID-15406
- Country of Publication:
- United States
- Language:
- English
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