THE TOXICOLOGIC AND PHARMACOLOGIC EFFECTS OF HAFNIUM SALTS
The toxicology and pharmacology of hafnium salts were investigated. Acute intraperitoneal toxicity of hafnyl chloride is of the delayed type with an LD/sub 50/ per 7 days of 112 of 1.0, 0.1, and 0.01% of the diet produced liver changes at the 1.0% level. No changes were observed in the growth rate or the hemogram. Ocular application produced a transient conjunctivitis. Topical application to intact rabbit skin produced a transient irritation, whereas similar studies on abraded skin resulted in nonhealing ulcers. Intradermal injections also produced localized irritation and scar formation. Hafnyl chloride had a depressant effect upon the isolated rabbit and guinea pig ileum. In the intact cat, the compound produced hypotension and death by cardiovascular collapse and respiratory paralysis. The chemical had no effect on the responses to acetylcholine, epinephrine, or histamine or those elicited by stimulation of the cervical sympathetic or vagus nerves. (auth)
- Research Organization:
- Univ. of California, Los Angeles
- NSA Number:
- NSA-16-031465
- OSTI ID:
- 4778854
- Journal Information:
- Toxicol. and Appl. Pharmacol., Journal Name: Toxicol. and Appl. Pharmacol. Vol. Vol: 4
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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