THE TOXICOLOGICAL AND PHARMACOLOGICAL EFFECTS OF GADOLINIUM AND SAMARIUM CHLORIDES
Technical Report
·
OSTI ID:4817623
A study was made of the toxicology and pharmacology of gadolinioum and samarium chlorides. The symptoms of acute toxicity following intraperitoneal injectmons are descriobed. The chronic oral ingestion of both chemicals for l2 weeks produced no effects on growth or the hemogram, and only the male rats receiving gadolinium chloride showed liver damage. The pharmacological responses to both chemicals were mainly depressant on all systems studied, and death was associated with cardiovascular collapse coupled with respiratory paralysis. The greatest damage seen was on abraded skin, where non-healing ulcers were produced by both chemicals. Irritation of mntact skin and ocular tissues was only transment in nature. (auth)
- Research Organization:
- California. Univ., Los Angeles. School of Medicine. Lab. of Nuclear Medicine and Radiation Biology
- NSA Number:
- NSA-16-002877
- OSTI ID:
- 4817623
- Report Number(s):
- UCLA-492
- Country of Publication:
- United States
- Language:
- English
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