Experimental Eczema. 16. Diminution of the Eczematous Reaction in Preirradiated Guinea Pigs (in French)
Irradiation of small areas of guinea pig skin with 1600 r produced persistent alopecia and acanthosis, without any other subsequent histologic or macroscopic changes in skin. Forty days after such local irradiation of skin, the animals were sensitized to chlorodinitrobenzene and skin reactions were tested with the same compound 7 days later on both the irradiated and control areas. In contrast to the intense eczema developing in control skin, irradiated skin showed a complete lack of reactivity to the allergen. lt was shown that the absence of reactivity in irradiated skin was not the result of the existing acanthosis, since acanthosis induced by applications of erucic acid did not block the eczematous response to the allergen. Nor was the lack of reactivity due to the absence of hair, since radiationinduced inhibition of eczema could be demonstrated in skin normally lacking hair (nipples).
- Research Organization:
- Universite, Geneva
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-020163
- OSTI ID:
- 4829295
- Journal Information:
- Dermatology, Journal Name: Dermatology Journal Issue: 3 Vol. 124; ISSN 1018-8665
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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