Experimental eczema. 12 effects of x-rays in experimental eczema (combined injury) (in French)
Contact dermatitis was induced in guinea pig nipples by local application of 2,4-dinitrochlorobenzene after previous sensitization. No effect of x irradiation on the histologic aspects of the developing dermatitis could be detected when doses of 800 or 1600 r were given 2 to 16 days after sensitization or repeated 100-r doses were given. Although a 800-r dose had no detectable effect on epithelium, it was found to alter the eczematous reaction when given 72 hr before the eliciting application of dinitrocitlorobenzene in sensitized animals. Eczematous epithelium in irradiated skin showed swelling of cells, indistinct cell boundaries, diminished numbers of nuclei, and fewer mitoses blocked by colchicine; none of these changes was produced by eczema alone. The changes in epidermis induced by irradiation with 800 r before eliciting eczema resembled those produced by much higher x-ray doses (2400 r), indicating that eczema augments the cellular changes induced by irradiation.
- Research Organization:
- Clinique Universitaire de Dermatologie, Geneva
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-002843
- OSTI ID:
- 4757948
- Journal Information:
- Dermatology, Journal Name: Dermatology Journal Issue: 3-4 Vol. 122; ISSN 1018-8665
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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