Mitoses-Acanthosis-X Rays (in French)
Marked acanthosts resulted 4 days after topical application of estrogen to the nipple of male guinea pigs. A relatively low dose of locally applied x radiation (400 r) completely inhibited the reaction, and the skin was refractory to estrogen-induced acanthosis for 5 days. With 1600 r the recovery phase was prolonged to 20 days. On other areas of guinea pig skin the reaction could be stimulated by estrogen, but other substances induced mitoses and acanthosis, such as erucic acid and chrysarobin. This reaction was also inhibited by x rays. Larger repeated doses of estrogen applied to the nipple of male guinea pigs caused mitotic activity and hypertrophy of the mammary gland resembling that seen in gravid females. This reaction was also inhibited by 400- r irradiation. Similar doses of x radiation were used to inhibit mitoses in some human skin lesions, such as condyloma acuminatum (venereal warts). Doses of 800 r were observed to diminish the number of mitoses (blocked by colchicine) in hair follicles also. By varying the x-ray tube voltage and Al filtration, it was possible to deliver appropriate doses to guinea pig mammary glands without causing appreciable changes in epidermis. It was also found that 70-kv operation with 0.5-mm Al filtration minimizes the effect of medicated ointments on human skin. (TCO)
- Research Organization:
- Clinique Universitaire de Dermatologie, Geneva
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-021502
- OSTI ID:
- 4718993
- Journal Information:
- Chemotherapia (Switzerland) Changed to Chemotherapy (Basel), Journal Name: Chemotherapia (Switzerland) Changed to Chemotherapy (Basel) Vol. Vol: 2; ISSN CMTRA
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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