Epilation induced by x-rays in guinea pigs (in French)
A 3-cm diameter area of guinea pig skin was irradiated with various doses to determine the min. dose inducing epilation. This dose was between 400 and 500 r since 400 r failed to induce it but 800 r consistently caused epilation. After 800 r the hair began to fall out between the 8th and 12th day and alopecia was macroscopically complete by the 11th to 15th day. The hair began to return during the 2nd month but even 3 to 4 months later regrowth of hair was incomplete and the irradiated zone was clearly distinguishable. Hair fell out more slowly after 1600 r than 800 r, and with the higher dose no regrowth of hair occurred during the 8-month observation period. Varying the quality of the x-rays, with the tube operated at 10 to 70 kv, had no effect. on the onset or duration epilation. Fractional doses given 1 day apart were much less effective than single doses, for example, four 200-r doses or eight 200-r doses caused no epilation although the total doses given singly were effective. Arrest of mitosis was not related to epilation, higher doses of x-rays were required to arrest mitosis in the hair bulb than in nipple epidermis or condylomata acuminatum (venereal warts).
- Research Organization:
- Clinique Universitaire de Dermatologie, Geneva
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-001281
- OSTI ID:
- 4766964
- Journal Information:
- Dermatology, Journal Name: Dermatology Journal Issue: 2 Vol. 123; ISSN 1018-8665
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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IS THE ROENTGEN DOSE NECESSARY FOR INDUCTION OF TEMPORARY EPILATION APPLIED TO HAIR FOLLICLES LESS WITH SOFT THAN WITH HARD RADIATION