Epilation Induced by X-Rays in the Guinea Pig (Fractionated Doses at Intervals of 6, 12, and 24 Hours) (in French)
A single dose of 800 r delivered to an area of guinea pig skin 3 cm in diameter regularly caused epilation. However, no epilation followed four 200-r doses given at intervals of 24 hr. or even after eight 200-r doses. In contrast, either of these fractional doses given at 12-hr intervals produced epilation. The same fractional doses at 6-hr intervals were also effective. A single 1600- r dose caused persistent alopecia compared with the transient (1- to 2month) hair loss caused by 800 r. However, if the 1600-r dose was given fractionally the duration of alopecia was diminished. These results in guinea pigs differ from results on fractional doses necessary to induce erythema in man. which showed that the effect diminished as the interval was decreased below 24 hr. The threshold epilatory dose is higher in guinea pigs than man. (H.H.D.)
- Research Organization:
- Clinique Universitaire de Dermatologie, Geneva
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-001282
- OSTI ID:
- 4773474
- Journal Information:
- Dermatologica (Switzerland), Journal Name: Dermatologica (Switzerland) Vol. Vol: 123; ISSN DERAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
Similar Records
SEROTONIN AND THE LOCAL EFFECT OF X RAYS. 2. SEROTONIN AND THE EFFECTS OF X RAYS ON MITOSES IN THE HAIR FOLLICLE AND RADIOLOGIC ACANTHOSIS
The effect of fractionated doses of x-rays. I. Experiments on the flank of guinea pigs. II. Preliminary results in a case of basal cell carcinoma and in case of ulcerated carcinoma of the breast