The effect of fractionated doses of x-rays. I. Experiments on the flank of guinea pigs. II. Preliminary results in a case of basal cell carcinoma and in case of ulcerated carcinoma of the breast (in French)
Local irradiation of the skin of guinea pigs with 200 r/day 6 days/week caused epilation after 35 to 49 days, corresponding to cumulative doses of 6000 to 8400 r. the threshold single dose for epilation was -- 800 r, which produced epilation after 11 to 15 days. With fractional doses of 100 r/day, epilation occurred after 100 to 160 days, or with cumulative doses of 8000 to 14,000 r. Ulcers appeared 63 to 145 days after 200-r daily doses, corresponding to cumulative doses of 11,000 to 25,000 r. No ulcers were noted after 100-r daily doses, up to total doses of 11,500 to 20,000 r, nor were any macroscopic changes in irradiated skin noted, other than epilation. On the basis of results obtained in these animal experiments, fractional therapeutic doses of x rays were applied to two inoperable patients with cancer, one with a basal cell carcinoma of the nose and another with metastatic breast cancer. Both cases were given daily doses of 25 to 50 r, up to total doses of 2800 r. The therapeutic results, which are illustrated, show regression of the superficial tumors and healing of previously ulcerated areas.
- Research Organization:
- Clinique Universitaire de Dermatologie, Geneva
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-032775
- OSTI ID:
- 4756300
- Journal Information:
- Dermatology, Journal Name: Dermatology Journal Issue: 3 Vol. 125; ISSN 1018-8665
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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