STUDIES ON THE COMBINED EFFECTS OF RADIATION AND VARIOUS CHEMICALS ON THE MITOTIC CELLS. XXV. EFFECT OF COMBINED USE OF X-RAYS AND MALEIC ACID
Journal Article
·
· Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
OSTI ID:4817914
The MTK-sarcoma was inoculated into the intraperitoneal cavities of mice, and 3 or 4 days later maleic acid and x rays were given. The frequency of mitosis, the difference of each mitotic phase in number, and the frequency of abnormality of chromosomes in metaphase and anaphase were investigated. When 0.04 mg of maleic acid per 100 g weight was given to the mice there was no change in the frequency of mitosis. On injecting 5 mg of maleic acid per 100 g body weight there was a slight decrease in mitosis soon after injection; after 9 to 12 hr it was found that there was a 40% increase in the frequency of mitosis. On injecting both quantities, 0.04 mg and 5 mg of maIeic acid, there was little marked transformation in morphology. lnjection of maleic acid after x irradiation showed no observable protective effect. Maleic acid had a protective effect on malonate which would inhibit the activlty of mitotic cells, but in this case maleic acid had no restorative effect. One hour after injection of maleic acid, the effect of malonate and the combined use of x rays was protective on mitosis but not restorative. It was concluded that maleic acid like fumaric acid exerted some influence on the pathway between succinic acid and funaric acid, and that maleic acid had a protective effect against x irradiation. (Abstr. Japan Med., 1: No. 15, 1961)
- Research Organization:
- Hokkaido Univ. School of Medicine, Sapparo
- NSA Number:
- NSA-16-008604
- OSTI ID:
- 4817914
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
STUDIES ON THE COMBINED EFFECT OF RADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XIII. EFFECT OF COMBINED USE OF X-RAYS AND SUCCINIC ACID
STUDY ON THE COMBINED EFFECTS OF RADIATION AND CHEMICALS. VIII. EFFECT OF THE COMBINED USE OF X-RAYS WITH FUMARIC AND MALONIC ACID ON SARCOMA MTK-III
STUDIES ON THE COMBINED EFFECT OF RADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XIV. EFFECT OF THE COMBINED USE OF X-RAY AND ACRIFLAVINE
Journal Article
·
Wed Dec 31 23:00:00 EST 1958
· Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
·
OSTI ID:4045188
STUDY ON THE COMBINED EFFECTS OF RADIATION AND CHEMICALS. VIII. EFFECT OF THE COMBINED USE OF X-RAYS WITH FUMARIC AND MALONIC ACID ON SARCOMA MTK-III
Journal Article
·
Wed Dec 31 23:00:00 EST 1958
· Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
·
OSTI ID:4044256
STUDIES ON THE COMBINED EFFECT OF RADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XIV. EFFECT OF THE COMBINED USE OF X-RAY AND ACRIFLAVINE
Journal Article
·
Wed Dec 31 23:00:00 EST 1958
· Nippon Igaku Hoshasen Gakkai Zasshi (Japan)
·
OSTI ID:4843772