STUDY ON THE COMBINED EFFECTS OF RADIATION AND CHEMICALS. VIII. EFFECT OF THE COMBINED USE OF X-RAYS WITH FUMARIC AND MALONIC ACID ON SARCOMA MTK-III
The combined effect of x rays with fumaric and malonic acid was described. About 3 to 6 days after transplantation of sarcoma MTK-III, adult rats of the Wistar strain were exposed to x-ray irradiation of 200 r. Aqueous solutions of the chemical agents were injected intraperitoneally. After injection of fumaric acid the mitotic index and the metaphase percentage increased slightly. This response was definite only when injection was given within 3 hr before irradiation. However, no morphological effect was found in the chromosomes. The administration of fumaric acid before x irradiation caused a marked decrease of x-ray effect. Malonic acid had an effect on mitosis similar to that of x irradiation. When malonic acid was used together with x irradiation, there was a combined effect, but fumaric acid and x rays had antagonistic effects. The author concluded that one of the effects of x rays on sarcoma MTKIII may be inhibition of the tricarbonic acid cycle in the succinic acid metabolism. (Abstr. Japan. Med., 1: No. 1,
- Research Organization:
- Hokkaido Univ., Sapporo
- NSA Number:
- NSA-15-022082
- OSTI ID:
- 4044256
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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