INVESTIGATIONS ON THE PROBLEM OF FORMATION AND PATHOPHYSIOLOGICAL SIGNIFICANCE OF BIOGENIC AMINES IN SUBLETHAL RADIATION INJURIES. II. ANNUAL TECHNICAL REPORT, COVERING THE PERIOD FROM OCTOBER 1, 1960-SEPTEMBER 30, 1961

Technical Report · Wed Oct 31 04:00:00 EST 1962

OSTI ID:4817551

Franzen, Fr

Investigations were carried out which furnished a specific proof of the radiation-induced formation of toxic substances. After a single short-timed total body irradiation of 400, 600, and 800 r a considerable increase of the excretion of 3-hydroxytyramine, 1-noradrenaline, adrenaline, tryptamine, 5- hydroxytryatamine, buiotenine, and histamine was observed in the urine of rats. It was also possible to prove an increase of the named aromatic amines in the blood of the irradiated rats. In a pathophysiological respect the observation of the timely correspondence between the abnormal occurrence of the biogenic amines and the development of the radiation syndrome was of a special importance. The amines found hitherto under these experimental conditions concern highly active compounds with an unusually wide spectrum of pharmacological and toxicological action. (auth)

• Research Organization: Cologne. Universitat. Medizinische Klinik
• NSA Number: NSA-16-002914
• OSTI ID: 4817551
• Report Number(s): NP-11062
• Country of Publication: United States
• Language: English

Related Subjects

ADRENALINE
AMINES
BIOLOGY AND MEDICINE
BUFOTENINE
ETHYL RADICALS
HETEROCYCLICS
HORMONES
INDOLES
ORGANIC NITROGEN COMPOUNDS
PHENOLS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
RATS
SEROTONIN
TOXICITY
TRYPTAMINES
URINE