THE EFFECT OF CYSTEAMINE ON THE X-RAY SENSITIVITY OF T2 BACTERIOPHAGES DURING THEIR INTRACELLULAR CYCLE

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Zeitschrift fuer Naturforschung (West Germany) Divided into Z. Nautrforsch., A, and Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,

OSTI ID:4816784

Marcovich, H

Radioprotection of phage T2 and of the monocomplex E. coli B/T2 was studied. Phage T2 is protected by cysteamine under conditions that exclude indirect effect mechanisms. Although there is no oxygen effect on this virus observable by removing the gas by physical means, it is suggested that the protector cysteamine acts by reducing some oxidized groups of the phage. The monocomplex can be protected only during the first five minutes of the latent period. The late monocomplex and the capacity of E. coli B to reproduce T2 are not protected by cysteamine. To explain these resuIts it is assumed that the molecules involved in the capacity-inactivation by X-rays are in a reduced state, in contrast to the structures whose alteration is responsible for the killing of the bacteria. (auth)

• Research Organization: Institut Pasteur, Paris
• NSA Number: NSA-16-020292
• OSTI ID: 4816784
• Journal Information: Zeitschrift fuer Naturforschung (West Germany) Divided into Z. Nautrforsch., A, and Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys.,, Journal Name: Zeitschrift fuer Naturforschung (West Germany) Divided into Z. Nautrforsch., A, and Z. Naturforsch., B: Anorg. Chem., Org. Chem., Biochem., Biophys., Vol. Vol: 17b; ISSN ZNTFA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

BACTERIOPHAGES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CYSTEAMINE
DRUGS
OXYGEN
RADIATION PROTECTION
RADIOSENSITIVITY
X RADIATION