THE ANALYSIS OF INJURIES AND REPARATIVE PROCESSES IN THE EMBRYOGENESIS OF RATS AFTER X-RAY IRRADIATION

Journal Article · Sat Oct 21 04:00:00 EDT 1961 · Doklady Akad. Nauk S.S.S.R.

OSTI ID:4814529

Val'shtrem, E A

It was observed that the administration of a total, x-ray dose of 130 r to the fetus of a rat on the 10th day after conception led to an increase in the percent of anomalous embryos during the first 3 days after irradiation, but that there was a significant decrease in the number of anomalous embryos after this 3 day period due to the effectiveness of reparative processes. Since it is well known that x-rays suppress the mitotic activity of cells, a comparison was made of the change in percent mitoses of brain cell tissue of irradiated and normal embryos. The mitotic activity of a normal embryo decreases from 42.13% on the 11th day to 27.32% on the 17th day of development. An embryo irradiated on the 10th day after conception shows only 11.68% of the cell dividing on the 11th day after conception (one day after irradiation). The mitotic activity of the irradiated embryo cells then increases until it approaches the normal level of about 28% on the 14th day after conception. The restoration of mitotic activity is a strong indication of reparative processes occurring in the embryonic brain. The greater the damage observed after irradiation, the lower is the mitotic activity observed in the embryonic, brain cell tissue. (TTT)

• Research Organization: Leningrad State Pedagogical Inst.; Inst. for Experimental Medicine, Academy of Medical Sciences, USSR
• NSA Number: NSA-16-005221
• OSTI ID: 4814529
• Journal Information: Doklady Akad. Nauk S.S.S.R., Journal Name: Doklady Akad. Nauk S.S.S.R. Vol. Vol: 140
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BRAIN
EMBRYOS
FETUSES
MITOSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RATS
RECOVERY
X RADIATION