STUDIES ON THE CHANGES OF THE BLOOD-FORMING ORGANS IN WEANING MICE AFTER X- IRRADIATION
After a single total-body x-irradiation of 600 r erythroblasts, granulocytes, and lymphocytes were markedly damaged and most of the cells disappeared within 24 hr. Hematopoietic tissues became aplastic within 72 hr. The lymphopoietic tissues were damaged more severely in the lymph nodes than in the spleen. Erythroblasts and granulocytes in the bone marrow and in the spleen began to regenerate on the 5th, and the lymphocytes in the spleen and the lymph nodes on the 5th to 7th days after exposure. At the stage of regeneration, the granulocytes multiplied markedly, whereas the erythroblasts did not regenerate in the bone marrow. On the other hand, multiplication of both erythroblasts and granulocytes was observed in the spleen at the same stage. Here the multiplication was more marked in the case of the erythroblasts than in the case of the granulocytes. Some of the erythroblasts showed hyperplasia on the l4th day after the exposure and the degree of multiplication was most marked on the 2lst day. These findings continued until the 70th day after the exposure. The lymphopoietic tissues were well regenerated both in the spleen and in the lymph nodes but this regeneration occurred later than in the case of myelopoietic tissues in the bone marrow and in the spleen. Aplasia of the bloodforming organs was observed in cases which died during the early stage, but regeneration was observed in those cases which lived for relatively long periods after the exposure. However, the lymphopoietic and erythropoietic tissues were generally poor after regeneration. These changes were considered to be important causes of death secondary to irradiation. The changes found in the bloodforming organs of weaning mice were essentially the same as those found in adult mice, but the degree of damage to the hematopoietic tissues was more severe than that found in adult mice. In spite of the severe damage, regeneration was prominent in weaning mice. The hyperplasia of erythroblasts in the spleen may accelerate recovery from injury in weaning mice. (auth)
- Research Organization:
- National Inst. of Animal Health, Tokyo
- NSA Number:
- NSA-16-004093
- OSTI ID:
- 4813400
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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