HISTOPATHOLOGICAL STUDIES ON THE EFFECT OF IRRADIATION WITH VARIOUS DOSES OF X-RAYS UPON THE HEMOPOIETIC TISSUE OF YOUNG MICE. II. CHANGES IN BONE MARROW

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Natl. Inst. Animal Health Quart. (Tokyo)

OSTI ID:4808120

Takahashi, I; Sakaki, K; Hirasawa, K; Tanaka, K

Histopathological observations were carried out on changes of the bone marrow of young mice irradiated with from 60 r to 600 r of x rays. Clear-cut damage was inflicted on the bone marrow even by irradiation with 60 r. Immature cells of the granulocyte series and some of the erythroblasts present were damaged by exposure to this dose of x rays. It was elucidated that the larger a dose of irradiation, the higher the severity of damage of the irradiated tissue. Damage was not only restricted to erythroblasts and immature cells of the granulocyte series, but also extended gradually to mature cells of the granulocyte series and megakaryocytes. Eventually, the bone marrow fell into a perfect state of aplasia after exposure to irradiation with 600 r. In every exposed animal, regardless of the dose of irradiation, the progression of damage was very rapid and accompanied by hyperemia and hemorrhage. The damage reached its maximum about 24 to 48 hours after irradiation. In general, the bone marrow underwent relatively rapid regeneration, in spite of their pronounced damage as mentioned above, and was restored to a normal state comparatively early. There were considerably great differences, however, in the progression of regeneration among the doses of x rays employed for irradiation, or among the degrees of severity of damage produced by irradiation. Erythroblasts were accompanied by pyknotic cells not infrequently in the early stage of regeneration after irradiation with a dose of 300 r or more of x rays. It showed unsatisfactory regeneration for a considerably long time in the succeeding period of restoration. Cells of the granulocyte series, however, proliferated relatively, showing a tendency to fall in hyperplasia. From these results, it is assumed that the erythroblasts may suffer severer damage than the cells of the granulocyte series when irradiated with a dose of 300 r or more. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-16-028796
• OSTI ID: 4808120
• Journal Information: Natl. Inst. Animal Health Quart. (Tokyo), Journal Name: Natl. Inst. Animal Health Quart. (Tokyo) Vol. Vol: 1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
CYTOLOGY
HEMORRHAGE
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
REGENERATION
X RADIATION