INVESTIGATION OF THE COURSE OF BONE MARROW REPOPULATION IN POSTIRRADIATION CHIMERAS OF RABBITS WITH PELGER'S ANOMALY

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Polskie Arch. Med. Wewnetrznej

OSTI ID:4083171

Czerski, P; Rosiek, O; Sablinski, J

Whole-body x irradiation doses of 1100 r (600 r + 500 r 24-hr later) were given 26 rabbits weighing 2.5 to 3 g, and some were injected with bone marrow cells from rabbits with the Pelger anomaly. In the recipient rabbits surviving 30 days or longer, circulating leukocytes showing the Pelger trait could be found. The proportion of Pelger granulocytes reached a maximum of 82% 14 days postirradiation, then declined to about 15% at 120 days, and disappeared from the circulation after 240 days. Normal peripheral cells showed an inverse relation, that is, are at minimal levels on the 14th day after irradiation. Donor (Pelger) cells could also be identified in the bone marrow of the surviving recipients. At the peak level of circulating Pelger cells (82% of the granulocytes at 14 days), 47% of the erythroblastic and 45% of the megakaryocytic cells were of donor (Pelger) origin. These results indicate the usefulness of this method of identification of the origin of peripheral and bone marrow cells in radiation chimeras. (BBB)

• Research Organization: Medical Academy, Warsaw
• NSA Number: NSA-18-013526
• OSTI ID: 4083171
• Journal Information: Polskie Arch. Med. Wewnetrznej, Journal Name: Polskie Arch. Med. Wewnetrznej Vol. Vol: 32
• Country of Publication: Country unknown/Code not available
• Language: Polish

Related Subjects

BIOLOGY AND MEDICINE
BODY
BONE MARROW
CHIMERAS
CYTOLOGY
ERYTHROCYTES
IRRADIATION
LEUCOCYTES
MEGAKARYOCYTES
PLATELETS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
TRANSPLANTS
WHOLE-BODY IRRADIATION