EYE ABNORMALITIES IN MOUSE EMBRYOS CAUSED BY X-IRRADIATION OF THE MOTHERS. CHANGES IN THE INITIAL STAGE OF DEVELOPMENT BY IRRADIATION ON THE 8th DAY OF PREGNANCY. (English Text)
Mice were exposed to a single whole-body x irradiation of 25 to 150 r on the 8th day of pregnancy. The embryos were removed on the 13th day of pregnancy and examined microscopically. Gross eye abnormalities ranged from microphthalmia to anophthalmia. The former were more frequent, and almost all were associated with abnormalities of the CNS. Microscopically, in those with extreme degrees of eye abnormalities, there were no cases believed to be primary anophthalmia. In hydrocephalic embryos, when the lumen of the optic stalk was wide and short, the optic cup was malformed and failed to reach the cranial subepi dermis and in such cases the lens was also lacking. In some cases of exencephaly and allied conditions, the axis of the optic cup was directed vertically, and the optic cup opened, without a lens, directly into the naesenchymal tissue under the brain. In many abnormal eyes, the inner wall of the primordial retina was everted in the margin of the choroid fissure, and a cystic cavity was formed by the duplicated inner and outer walls. Such cases present changes quite similar to those seen in the development of hereditary uvea coloboma and bulbus cyst. (Abstr. Japan Med., 2: No. 6, June 1962)
- Research Organization:
- Nagoya Univ. School of Medicine, Japan
- NSA Number:
- NSA-16-025215
- OSTI ID:
- 4804571
- Journal Information:
- Nagoya Journal of Medical Science (Japan), Journal Name: Nagoya Journal of Medical Science (Japan) Vol. Vol: 24: No. 2; ISSN NJMSA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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