Congenital abnormalities in methylmercury poisoning

Journal Article · Tue Apr 01 04:00:00 EDT 1975 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(75)90057-2· OSTI ID:7297837

Gilani, S H

This study was undertaken to determine the teratogenic potential of methylmercury on chick embryogenesis. Methylmercuric chloride was dissolved in sodium bicarbonate (0.2%) and administered to the chick embryos at doses ranging from 0.0009 to 0.010 mg per egg. The injections were made at days 2 and 3 on incubation (Groups A and B). All the embryos including controls were examined on the 7th day of incubation. Methylmercury poisoning was observed to be both embryolethal and teratogenic. Within the two groups, embryolethality was higher in Group A. The following congenital abnormalities were observed: exencephaly, shortened and twisted limbs, microphthalmia, shortened and twisted neck, beak abnormalities, everted viscera, reduced body size and hemorrhage all over the body. Exencephaly and limb abnormalities were very common. No differences in the incidence and types of gross abnormalities within both the groups (A and B) were noted. The incidence of malformations among the controls was low. The results of present investigation show that methylmercury poisoning is both embryolethal and teratogenic to early chick embryogenesis. (auth)

• Research Organization: New Jersey Medical School, Newark
• OSTI ID: 7297837
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 9:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
CHICKENS
CONGENITAL MALFORMATIONS
DISEASES
EMBRYOS
FOWL
MALFORMATIONS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PATHOLOGICAL CHANGES
TERATOGENESIS
VERTEBRATES