The effect of nicotinic acid amides on the radiation sensitivity of tumor cells and whole-body x-irradiated mice

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Naturwissenschaften

DOI:https://doi.org/10.1007/BF00591213· OSTI ID:4804117

Koch, R.; Seiter, I.

Along with the H₂O₂-induced inhibition of glycolysis, there is a decrease of the DPN concentration, which the addition of nicotinic acid amide normalizea. A study was made to determine if the amide, on this basis, represents a radiatlon protective substance both for tumor and tissue cells. The addition of nicotinic acid to suspensions of Ehrlich ascites before irradiatlon of the suspension gives a protective effect corresponding to the protection given by cysteamine or serotonin. A corresponding study was made to determlne lf nicotinic acid amide offered a protective effect for mammals. The amide was injected into mice before irradiation. The results showed that the nicotinic acid amlde gave radiation protection to tumor cells, bdit not to normal tissue.

• Research Organization: Universitat, Freiburg i. B.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-006335
• OSTI ID: 4804117
• Journal Information: Naturwissenschaften, Journal Name: Naturwissenschaften Journal Issue: 19 Vol. 48; ISSN 0028-1042
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
AMIDES
AMINES
ANIMAL CELLS
CYSTEAMINE
HYDROGEN PEROXIDES
MICE
RADIATION PROTECTION
RADIOSENSITIVITY
TISSUES
TUMORS
VITAMIN PP
VITAMINS
X RADIATION