ON THE MECHANISM OF THE RADIOPROTECTIVE EFFECT OF NICOTINIC ACID AMIDE ON EHRLICH ASCITES TUMOR (in German)
Journal Article
·
· Arzneimittel-Forsch.
OSTI ID:4658853
Previous studies provided evidence of the protective effects of nicotinamide (NA) against radiation in the Ehrlich ascites tumor. Its effect was further studied to determine whether the protective effect is connected with the function of NA in diphosphopyridine nucleotide (DPN) and thus with anaerobic glycolysis. Irradiation of Ehrlich ascites cells with x rays results in inhibition of anaerobic glycolysis and in reduction of the resting DPN content. Both these processes are protected by addition of NA. The protection of DPN requires higher doses of NA than does that of glycolysis. Whereas glycolysis is completely inhibited following irradiation with 70 kr, 28% of the original content of stationary DPN may still be recovered following the same radiation dose. The mechanisms underlying the protection of glycolysis and resting DPN content may not, however, explain the protection of tumor growth, because this is much more sensitive to radintion than glycolysis or DPN content. Experimerts with 6-aminonicotinamide revealed no new aspects relevant to the protection of tumor growth by NA, since this antagonist of NA did not influence radiosensitivity. (BBB)
- Research Organization:
- Universitat, Freiburg i. B.
- NSA Number:
- NSA-17-035478
- OSTI ID:
- 4658853
- Journal Information:
- Arzneimittel-Forsch., Journal Name: Arzneimittel-Forsch. Vol. Vol: 12
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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OSTI ID:4117663
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Thesis/Dissertation
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Sun Dec 31 23:00:00 EST 1961
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OSTI ID:4665673