The modification of the fine structure of irradiated liver cells

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Naturwissenschaften

DOI:https://doi.org/10.1007/BF00592850· OSTI ID:4803876

Braun, Hildegard; M�ller, Johannes

BS>A study was made to determine at what place in the liver parenchym cells at sublethal and lethal doses the radiation damage in the ultra-structural ram, e is first morphologically detectable, and whether the succession of structure changes always follows the same path. Mice were irradiated with doses of 800, 3200, 6400, and 9600 r and then sacrificed after 30 min, and 6, 12, and 24 hrs. The results showed that first a damage to the ergastoplasmatic structure and a compression of the cytoplasm occurs. The mitochondria undergoes for the most part a transient surface change (formation of lumps). Size and interior structure were first aitered usually at 800 and 3200 r after 12 hrs, whereas at 6400 r and above all at 9600 r size increase and structure damage occurred 30 min after the irradiation. At 800, 3200, and partially at 6400 r, the cavity of the endoplasmatic lamella swell independently and chronologically before the mitochrondria.

• Research Organization: Universitat, Freiburg i. B.; and Heiligenberg-Institutes, Heilingenberg, Ger.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-009884
• OSTI ID: 4803876
• Journal Information: Naturwissenschaften, Journal Name: Naturwissenschaften Journal Issue: 21 Vol. 48; ISSN 0028-1042
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
CYTOLOGY
LETHAL DOSE
LIVER
MICE
MITOCHONDRIA
RADIATION DOSES
RADIATION EFFECTS