THE EFFECT OF X-RAY IRRADIATION ON RAT BONE MARROW BY AUTORADIOGRAPHIC STUDIES USING TRITIUM-LABELLED THYMIDINE. III. COMPARISON BETWEEN VARIOUS KINDS OF BONE MARROW CELLS AND PERIPHERAL BLOOD CELLS. SOME CONSIDERATIONS ON ABSCOPAL EFFECT OF X-IRRADIATION
Rats were exposed to 600 r whole-body irradiation. It was found that the large and small lymphocytes were very radiosensitive irrespective of their DNA-synthesizing ability. In this respect they were similar to K-s cells of the erythropoietic series, though the reticulum and plasma cells remained radioresistant. The maximum inhibitory effect on DNA-synthesizing ability, indicated by a reduction of grain counts, was seen 6 hr after irradiation. lt was followed by gradual recovery to normal 12 hr later in every kind of bone marrow cell. The grade of inhibition was greater in cells having active DNA- synthesizing ability. The difference in radiosensitivity between labeled and unlabeled cells was eompared and considered. The percentage of thymidine uptake, the distribution of grain counts over cells, and their mean grain counts were tabulated for every kind of bone marrow cell and for peripheral DNA-synthesizing blood cells. Negligible DNA-synthesizing ability was found in small lymphocytes and plasma cells. (Abstr. Japan Med., 1: No. 16, 1961)
- Research Organization:
- Yokohama Univ. School of Medicine, Japan
- NSA Number:
- NSA-16-008600
- OSTI ID:
- 4801115
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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