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Bone marrow syndrome after lethal whole body irradiation in the dog. Part 1. Quantitative and qualitative analysis of the peripheral blood and bone marrow cellularity

Journal Article · · Haematologia (Budapest), v. 5, no. 1-2, pp. 67-78
OSTI ID:4389521
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The bone marrow syndrome was investigated in dogs subjected to 400 R whole-body irradiation. Hematological and morphological examinations of peripheral blood revealed progressive pancytopenia. After the early disappearance of the youngest nucleated bone marrow cells, the bone marrow cellularity dropped to a low level in 5 days and remained constant till death. Quantitative data obtained in the first 24 hrs after irradiation showed an immediate and nearly complete impairment of hematopoiesis with the normoblasts having the highest radiosensitivity. An increase in the normoblast, lymphocyte, reticulum cell, and plasmocyte counts was observed after 6 days, while the number of myeloid cells decreased further. The increase suggested a tendency to recovery in the preterminal phase. A relation may exist between the increase of the lymphocyte and reticulum-like cell counts and hematological recovery. (INIS)
Research Organization:
Lab. for Physiopathology, Leuven, Belg.
NSA Number:
NSA-29-005333
OSTI ID:
4389521
Journal Information:
Haematologia (Budapest), v. 5, no. 1-2, pp. 67-78, Journal Name: Haematologia (Budapest), v. 5, no. 1-2, pp. 67-78; ISSN HAEMB
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

*BONE MARROW CELLS-- RADIOSENSITIVITY
*BONE MARROW-- BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD FORMATION
DOGS
IONIZING RADIATIONS
LETHAL IRRADIATION
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
WHOLE-BODY IRRADIATION