Bone marrow syndrome after lethal whole body irradiation in the dog. Part 2. Iron kinetics
Journal Article
·
· Haematologia (Budapest), v. 5, no. 1-2, pp. 79-85
OSTI ID:4386970
Studies of iron kinetics in heavily irradiated dogs showed an immediate and severe impairment of hematopoiesis. The marked rise of the serum iron level observed on the first day after irradiation could be due to a decreased iron utilization but may also be ascribed to iron liberated from the destroyed normoblasts. Plasma iron clearance time increased after the irradiation, indicating a heavily disturbed iron metabolism. Plasma iron turnover, in contrast with the increase of plasma iron clearance and the low iron utilization, remained relatively high in the dogs that had received the iron 24 hrs after irradiation. This may indicate that a large amount of the iron removed from the blood is not used for efficient erythropoesis. In the dogs that had received the /sup 59/Fe 24 hrs after irradiation, iron utilization on the 9th day was in good agreement with the bone marrow cellularity 24 hrs after irradiation. In view of the fast bone marrow depopulation, the high iron utilization in the group of dogs that received /sup 59/Fe 6 hrs before irradiation shows that a great amount of the iron must be incorporated by the smaller number of surviving normoblasts and the more mature normoblasts and reticulocytes that are less radiosensitive and leave the bone marrow soon. (INIS)
- Research Organization:
- Lab. for Physiopathology, Leuven, Belg.
- NSA Number:
- NSA-29-005336
- OSTI ID:
- 4386970
- Journal Information:
- Haematologia (Budapest), v. 5, no. 1-2, pp. 79-85, Journal Name: Haematologia (Budapest), v. 5, no. 1-2, pp. 79-85; ISSN HAEMB
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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