THE EFFECT OF X-RAY IRRADIATION ON RAT BONE MARROW DETERMINED BY AUTOGRAPHIC STUDIES USING TRITIUM-LABELLED THYMIDINE
Erythroid precursors following x irradiation of 600 r to the rat were studied on the basis of cytological changes and ability to synthesize DNA over the first 24 hr. Decrease in number of red cell precursors was most marked, especially in the earlier stage. The number of cells capable of synthesizing DNA decreased more rapidly than that of similar cells not concerned in DNA synthesis. The marked effect on DNA-synthesizing ability was considered to be due partiy to an inhibition. It was probably due also to development of cells into the non-DNA- synthesizing stationary stage and failure of replacement due to cell death. A slight and transient effect was observed on shielded bone marrow, the number of labelled cells, the granule count, and the number of mitotic figures. (Abstr. Japan Med., 2, No. 2, Feb. 1962)
- Research Organization:
- Yokohama Univ. School of Medicine, Japan
- NSA Number:
- NSA-16-014558
- OSTI ID:
- 4785220
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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