THE EFFECTS OF RADIATION ON TOTAL AND DNA SYNTHESIZING CELLS OF THE BONE MARROW AND BLOOD
Rats were exposed to 800 r and the cellularity, cytology, and abtlity to synthesize DNA as indicated by the use of H-3 thymidine and autoradiography were studied in the bone marrow in myelocytic precursors for the first 24 hours following exposure. A loss in the absolute number of early myelocytlc precursors was noted over the ftrst few hours following the exposure, although the total number of myelocytic forms in the bone marrow was not affected profoundly. With the lapse of time, the percentage of more mature myelocytic elemerts increased. The absolute number of labeled cells in all mitotable compartmerts decreased considerably more rapidly than did the total number of similar cells. A marked effect on DNA synthesizing ability was reflected in an early and marked decrease in grain counts of individual cells; however some recovery of the ability to synthesize DNA was noted. The reasons for a later increase in grain counts per cell are discussed. The number of labeled cells in the peripheral blood was affected markedly by radiation over the time period studied but initially also by the anesthetic. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y.
- DOE Contract Number:
- AT(30-2)-GEN-16
- NSA Number:
- NSA-17-007786
- OSTI ID:
- 4740870
- Report Number(s):
- BNL-5915
- Country of Publication:
- United States
- Language:
- English
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