PROTECTION OF CELLS IN TISSUE CULTURE BY MEANS OF CYSTEAMINE AND CYSTAMINE AGAINST THE ACTION OF NITROGEN MUSTARD AND X-RAYS
Studies were made of the protective effects of cystea mine and cystamine against x radiation and nitrogen mustard damage to cells in tissue cultures. Both cysteamine and cystamine afford good protection against nitrogen mustard (HN2), whereas under the same experimental conditions no definite protection of the cultures is obtained against x irradiation with doses of 1160, 870, 580, 290, and 145 r. The results suggest that thc mechanisms of the protective action of cysteamine against x rays and nitrogen mustards are different. It is emphasized that radioprotection of isolated cells may be obtained under other experimental conditions and with other cell types. The protection obtained against nitrogen mustard supports the view that destruction of SH groups in the cell plays a central part in the biological effect of HN2. (auth)
- Research Organization:
- Univ. of Aarhus, Denmark
- NSA Number:
- NSA-16-012887
- OSTI ID:
- 4800472
- Journal Information:
- Biochemical Pharmacology (England), Vol. Vol: 8; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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