STUDIES OF THE MECHANISM OF THE PROTECTIVE ACTION OF SULPHYDRYL COMPOUNDS AND AMINES AGAINST NITROGEN MUSTARD (HN2) AND ROENTGEN IRRADIATION IN MICE

Journal Article · Sun Mar 01 04:00:00 EST 1959 · Biochemical Pharmacology (England)

DOI:https://doi.org/10.1016/0006-2952(59)90112-1· OSTI ID:4223865

Therkelsen, A J

It is shown that glutathione (GSH) lowers the lethal effect of cysteamine in mice, just as previous investigations suggested that GSH lowers the cytotoxic effect of cysteamine in tissue-culture experiments. It is also shown that GSH does not change the radioprotective action of cysteamine, and that it increases the ability of cysteamine to protect mice against nitrogen mustard (HN2). Accordingly, the present investigation weighs against the assumption that the mechanism of the toxic effect of cysteamine is identical to that of the protective action of the compound against x rays and HN2, as claimed by Eldjarn and Pihl. Comparative studies on the protection against x rays and HN2 afforded by cysteamine, some cysteamine derivatives, tryptamine. tyramine, and aminoethyliso-thiouronium-hydrobromide (AET) are reported, and the results are discussed. It is emphasized that after a LD/sub 98.5/ of HN2 death of the animals seems to be due to intestinal destruction, while the cause of death after a LD/sub 97/ of x irradiation is apparently destruction of the bone marrow. (auth)

• Research Organization: Univ. of Aarhus, Denmark
• NSA Number: NSA-13-017672
• OSTI ID: 4223865
• Journal Information: Biochemical Pharmacology (England), Journal Name: Biochemical Pharmacology (England) Vol. Vol: 1; ISSN BCPCA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
AMINES
AMINO ACIDS
BIOLOGY AND MEDICINE
BONE MARROW
CYSTEAMINE
CYTOLOGY
GLUTATHION
HYDROGEN COMPOUNDS
INTESTINE
LETHAL DOSE
MICE
NITROGEN MUSTARD
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION INJURIES
RADIATION PROTECTION
SULFUR COMPOUNDS
TOXICITY
TRYPTAMINES
TYRAMINE
VARIATIONS
X RADIATION