COMBINED TREATMENT OF A TRANSPLANTABLE MOUSE TUMOUR WITH CYSTEAMINE ($beta$- MERCAPTOETHYLAMINE) AND NITROGEN MUSTARD (HN2)

Journal Article · Wed Jan 01 04:00:00 EST 1958 · Biochem. Pharmacol

OSTI ID:4173351

Therkelsen, A J

The tonic effect of cysteamine was studied after repeated injections into AKA mice. In a series of experiments in which a lymphocytic neoplasm was transplanted into AKA mice it was shown: that cyateamine and nitrogen mustard (HN2) exert an additive effect on the size of the subcutaneously transplanted tumor but that this effect is probably due to the weight loss which occurs during the treatment of the animals; that cysteamine has no therapeutic effect on the tumor used; that cysteamine given 4 to 6 hr before AN2 does not affect the increased survival time produced by HN2; and that cysteamine given 15 to 20 min before HN2 does not reduce the increased survival time produced by HN2 but that a considerably greater increase in survival time can be obtained by a combination of the two drugs than when HN2 is given alone, since cysteamine seems to afford a certain protection against the lethal effect of HN2 without a simultaneous reduction in the tumor-inhibitory effect of the latter. It is therefore concluded that the protective effect of cysteamine against HN2 can scarcely be explained by an inactivation of the latter by its linkage to the SH group of cysteamine. Other possible explanations of the effect are discussed. (auth)

• Research Organization: Univ. of Aarhus, Denmark
• NSA Number: NSA-14-013565
• OSTI ID: 4173351
• Journal Information: Biochem. Pharmacol, Journal Name: Biochem. Pharmacol Vol. Vol: 1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
MICE
NITROGEN MUSTARD
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
TOXICITY
TRANSPLANTS
TUMORS