Effects of Nitrogen Mustard on Mouse Tissue and Modification by AET
Journal Article
·
· International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
Clinical and pathological effects were investigated in RF/Up mice injected intravenously with a radiomimetic agent, nitrogen mustard, as well as the protection from these effects afforded by a radioprotective agent, aminoethylisothiuronium (AET). The effectiveness of HN2 was reduced about 40% by pre-injection with 9.0 mg of AET per mouse, raising the LD50/30 days from 0.127 to 0.203 mg per mouse. Symptoms of HN2-toxicity were also reduced through the use of AET, as was damage to tissues, especially cerebral, hemopoietic, and gastro-intestinal. Recovery began earlier and was more rapid in AETtreated mice. Although the specific cause of death was not ascertained, the results suggested that damage to the central nervous system probably played a significant part.
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-017418
- OSTI ID:
- 4780879
- Journal Information:
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Journal Name: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Journal Issue: 6 Vol. 4; ISSN 0020-7616
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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