Radioprotective effect of glutathione, cysteamine, and AET on mice from repeated exposures to x rays (in Japanese)
Mice of dd strain were exposed repeatedly to 300 R at one week intervals to their death. Pretreatment of glutathione (GSH), cysteamine and aminoethylisothiuronium (AET) showed radioprotective effect from radio-induced killing of animals. GSH was given at 30 min., 3 hours, and 6 hours prior to irradiation and a clear radioprotective effect was observed when the drug was given at 30 min. or 3 hours before irradiation. Drug administration at 6 hours before exposure was not so effective. Posttreatment of these agents showed no effect. GSH of 30 mg demonstrated most effective protection among the doses tested. AET of 3 mg or 6 mg and mercaptoethylamine (MEA) of 2 mg suggested radioprotective effects, and AET of 6 mg was the most effective among the SH compounds tested. (auth)
- Research Organization:
- Yamaguchi Univ., Japan
- NSA Number:
- NSA-29-018626
- OSTI ID:
- 4367733
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 8, pp. 689-692, Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 8, pp. 689-692; ISSN NHGZA
- Country of Publication:
- Japan
- Language:
- Japanese
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