RADIOMIMETIC AGENTS AND X-RAYS IN MICE AND AET PROTECTIVENESS. COMPARATIVE PATHOLOGICAL EFFECTS

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med.

OSTI ID:4724354

Asano, M; Odell, Jr, T T; McDonald, T P; Upton, A C

The clinicopathological effects of x-rays, mechlorethamine hydrochioride (HN/sub 2/. HCl), triethylenemelamine (TEM), busulfan (Myleran), and 4M20 were studied in young adult mice of the RF/Up and (101 X C3H)F/sub 1//Cum strains. The LD/sub 50//30 days of these agents were as follows: x rays, 613 r; mechlorethamine hydrochloride, 0.127 mg per mouse; TEM, 0.073 mg per mouse; busulfan, 1.01 mg per mouse; 4M20, 4.41 mg per mouse. The mean time of death varied with the agent and dose; at the LD/sub 50//30 day level it was 13.0 days after x rays, 12.4 days after busulfan, 6.9 days after mechiorethamine, 5.9 days after TEM, and 3.5 days after 4M20. The predominant sites of injury varied with the agent as follows: x rays, hematopoietic organs and gonads; busulfan, hematopoietic organs, gastrointestinal tract, gonads; mechiorethamine, brain, hematopoietic organs, gastrointestinal tract, and gonads; TEM, hem atopoietic organs, gastrointestinal tract, and gonads; 4M20, liver, hematopoietic organs, and gonads. Injury to the brain by mechlorethamine and to the liver by 4M20 were effects peculiar to these two agents. Pretreatment of the mice with AET reduced the severity of injury to some organs from x rays and mechlorethamine but did not detectably alter the injury resulting from TEM. Paradoxically, AET pretreatment increased the severity of injury by 4M20 in the intestine and bone marrow. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-17-019817
• OSTI ID: 4724354
• Journal Information: Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med., Journal Name: Archives of Pathology (U.S.) Formerly Arch. Pathol. Lab. Med. Formerly AMA Arch. Pathol. Changed back to Arch. Pathol. Lab. Med. Vol. Vol: 75; ISSN ARPAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
AGE
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
BRAIN
CHEMICALS
DRUGS
GONADS
INTESTINE
LETHAL DOSE
LIVER
MICE
MYLERAN
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOMIMETIC DRUGS
SURVIVAL TIME
TISSUES
TOXICITY
X RADIATION